缓激肽在豚鼠体内的支气管收缩作用。
The bronchoconstrictor action of bradykinin in the guinea-pig.
作者信息
COLLIER H O, HOLGATE J A, SCHACHTER M, SHORLEY P G
出版信息
Br J Pharmacol Chemother. 1960 Jun;15(2):290-7. doi: 10.1111/j.1476-5381.1960.tb01247.x.
Bradykinin was found to be a potent bronchoconstrictor agent in the guinea-pig anaesthetized with urethane. This action was not affected by vagotomy, or by treatment of the animal with mepyramine, atropine, lysergic acid diethylamide, or cortisone. Adrenaline and isoprenaline suppressed the bronchoconstrictor responses to bradykinin and histamine. Small doses of acetylsalicylic acid, however, suppressed only that to bradykinin. Bradykinin also produced bronchoconstriction in the isolated perfused lungs of the guinea-pig. The closely related peptide, wasp kinin, was also a potent bronchoconstrictor.
在使用乌拉坦麻醉的豚鼠中，发现缓激肽是一种强效支气管收缩剂。这种作用不受迷走神经切断术的影响，也不受用美吡拉敏、阿托品、麦角酸二乙胺或可的松处理动物的影响。肾上腺素和异丙肾上腺素可抑制对缓激肽和组胺的支气管收缩反应。然而，小剂量的乙酰水杨酸仅抑制对缓激肽的反应。缓激肽在豚鼠离体灌注肺中也可引起支气管收缩。密切相关的肽——黄蜂激肽，也是一种强效支气管收缩剂。
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