Page W V, Perlman S, Smith F G, Segar J L, Robillard J E
Department of Pediatrics, College of Medicine, University of Iowa, Iowa City 52242.
Am J Physiol. 1992 Mar;262(3 Pt 2):R459-63. doi: 10.1152/ajpregu.1992.262.3.R459.
The role of renal nerves in regulating changes in plasma renin activity (PRA) and renal renin gene expression was studied in intact (n = 6) and denervated (n = 6) fetal sheep before birth and during the first 24 h after delivery. Renal denervation completely blunted the rise in PRA observed 24 h after delivery in newborn lambs; in lambs with intact kidneys, PRA increased significantly (P less than 0.05) from 3.26 +/- 0.60 (predelivery) to 6.34 +/- 1.85 ng angiotensin I (ANG I).ml-1.h-1 (24 h postdelivery), while in lambs with denervated kidneys, predelivery and post-delivery values were 2.84 +/- 0.19 and 2.49 +/- 0.45 ng ANG I.ml-1.h-1, respectively. Renin mRNA levels were significantly lower (P less than 0.001) in denervated than in intact kidneys 24 h after birth. A close analysis of these results also revealed that renin mRNA levels were significantly higher (P less than 0.001) in intact kidneys of newborn lambs delivered vaginally (n = 3) than in newborn lambs delivered by cesarean section (n = 3). These results suggest that renal nerves play an important role in regulating renin gene expression and PRA during the transition from fetal to newborn life.
在出生前及出生后最初24小时，研究了完整（n = 6）和去神经支配（n = 6）的胎羊中肾神经在调节血浆肾素活性（PRA）和肾素基因表达变化中的作用。肾去神经支配完全消除了新生羔羊出生后24小时观察到的PRA升高；在肾脏完整的羔羊中，PRA从3.26±0.60（产前）显著增加（P<0.05）至6.34±1.85 ng血管紧张素I（ANG I）·ml-1·h-1（出生后24小时），而在肾去神经支配的羔羊中，产前和产后的值分别为2.84±0.19和2.49±0.45 ng ANG I·ml-1·h-1。出生后24小时，去神经支配的肾脏中肾素mRNA水平显著低于完整肾脏（P<0.001）。对这些结果的仔细分析还显示，经阴道分娩的新生羔羊（n = 3）的完整肾脏中肾素mRNA水平显著高于剖宫产出生的新生羔羊（n = 3）（P<0.001）。这些结果表明，在从胎儿到新生儿的生命转变过程中，肾神经在调节肾素基因表达和PRA中起重要作用。
