Parry D A, Steinert P M
Department of Physics and Biophysics, Massey University, Palmerston North, New Zealand.
Curr Opin Cell Biol. 1992 Feb;4(1):94-8. doi: 10.1016/0955-0674(92)90064-j.
In the past year, several new developments concerning the structure of intermediate filament proteins and their assembly into intact intermediate filaments have been made: the coiled-coil structure of a rod domain has been elucidated; the basis of the chain interaction and its role in intermediate filament assembly has been specified; the organization of nearest-neighbour molecules in keratin intermediate filaments has been determined; and the glycine loop structures of the terminal domains of epidermal keratin chains have been defined. In addition, mutations in intermediate filament chains that promote pathology have been reported for the first time.
在过去的一年里，关于中间丝蛋白的结构及其组装成完整中间丝有了一些新进展：杆状结构域的卷曲螺旋结构已被阐明；链间相互作用的基础及其在中间丝组装中的作用已被明确；角蛋白中间丝中相邻分子的组织方式已被确定；表皮角蛋白链末端结构域的甘氨酸环结构已被界定。此外，首次报道了促进病变的中间丝链中的突变。
