肾移植中供体-受体选择的混合白细胞培养不相容指数

Mixed leukocyte culture incompatibility index for donor-recipient selection in kidney transplantation.

作者信息

Uehling D T, Segall M, Hussey J L, Wank R, Kan C M, Bach F H

出版信息

J Urol. 1977 Jan;117(1):7-9. doi: 10.1016/s0022-5347(17)58317-2.

Abstract

The mixed leukocyte culture test has been applied to selection of histocompatibility non-identical donor-recipient pairs for renal transplantation. The clinical course of transplant recipients who have histocompatibility mismatches but low mixed leukocyte culture stimulation is similar to that of mixed leukocyte culture and histocompatibility identical recipients. Living donor-recipient pairs with high mixed leukocyte culture stimulation had no better graft survival than cadaver recipients. An incompatibility index derived from mixed leukocyte culture may aid in the selection of satisfactory non-identical living related donors and may help avoid use of immunologically unsatisfactory living donors.

摘要

混合淋巴细胞培养试验已应用于肾移植中组织相容性不匹配的供体-受体对的选择。组织相容性不匹配但混合淋巴细胞培养刺激较低的移植受者的临床病程与混合淋巴细胞培养和组织相容性匹配的受者相似。混合淋巴细胞培养刺激较高的活体供体-受体对的移植物存活率并不比尸体供体受者更好。从混合淋巴细胞培养得出的不相容指数可能有助于选择合适的非同卵活体亲属供体，并有助于避免使用免疫效果不理想的活体供体。