Vercellini P, Rossi R, Pagnoni B, Fedele L
Department of Obstetrics and Gynecology, Mangiagalli, University of Milano School of Medicine, Italy.
Obstet Gynecol. 1992 May;79(5 ( Pt 2)):838-9.
A healthy young woman with recurrent spontaneous abortion and septate uterus underwent hysteroscopic metroplasty with intracavitary instillation of 1350 mL of 10% dextran 40 in normal saline. After the operation, the patient developed acute hypervolemic pulmonary edema and severe coagulopathy due to temporary impairment of platelet function. Fluid overload, which could have been caused by the hyperosmolar properties of dextran, worsened progressively as fluids were drawn from the interstitial space and urine output was reduced. The use of a dilute and/or low-molecular-weight dextran solution to distend the uterine cavity during operative hysteroscopy is not without risk of complications.
一名患有复发性自然流产且子宫纵隔的健康年轻女性接受了宫腔镜子宫成形术，术中向宫腔内注入了1350毫升10%的右旋糖酐40生理盐水溶液。术后，患者因血小板功能暂时受损出现了急性容量负荷过重性肺水肿和严重凝血功能障碍。右旋糖酐的高渗特性可能导致的液体超负荷，随着液体从组织间隙吸出且尿量减少而逐渐加重。在宫腔镜手术中使用稀释和/或低分子量右旋糖酐溶液来扩张宫腔并非没有并发症风险。
