Bedani P L, Perini L, Farinelli R, Fabbian F, Fiocchi O, Guerra S, Vanini A, Gilli P
Division of Nephrology, S. Anna Hospital, Ferrara, Italy.
Angiology. 1992 May;43(5):408-11. doi: 10.1177/000331979204300506.
Four uremic patients with advanced peripheral arterial occlusive disease (PAOD) of lower limbs causing rest pain and ischemic-necrotic lesions were treated with a four-hour intravenous infusion of iloprost at doses of 0.75-2.5 ng/kg/min for twenty-eight days. After a week of the therapy all patients experienced disappearance of rest pain and prolonged walking distance. At the end of the trial a diabetic patient showed a complete regression of the necrotic areas of two toes while the other patients still showed ischemic-necrotic foot lesions that were well demarcated. Iloprost therapy can be effective in uremic patients with severe PAOD.
四名患有晚期下肢外周动脉闭塞性疾病（PAOD）并伴有静息痛和缺血性坏死病变的尿毒症患者，接受了为期28天的伊洛前列素静脉输注治疗，输注时间为4小时，剂量为0.75 - 2.5纳克/千克/分钟。治疗一周后，所有患者的静息痛消失，行走距离延长。试验结束时，一名糖尿病患者的两个脚趾坏死区域完全消退，而其他患者仍有界限清晰的缺血性坏死足部病变。伊洛前列素治疗对患有严重PAOD的尿毒症患者可能有效。
