伊洛前列素对静息痛患者的疗效。

The effect of iloprost in patients with rest pain.

作者信息

Volteas N, Leon M, Labropoulos N, Christopoulos D, Boxer D, Nicolaides A

机构信息

Irvine Laboratory for Cardiovascular Investigation and Research, St Mary's Hospital Medical School, London, U.K.

出版信息

Eur J Vasc Surg. 1993 Nov;7(6):654-8. doi: 10.1016/s0950-821x(05)80712-1.

DOI:10.1016/s0950-821x(05)80712-1

PMID:7505752

Abstract

Thirty-four patients with ischaemic rest pain in 42 limbs and ankle pressure equal to or less than 50 mmHg have been treated with intravenous infusion of synthetic prostacyclin (iloprost) for eight days. Leg blood flow was measured with air plethysmography before treatment, on day 4 and day 8 of treatment. Total relief of pain for at least 6 weeks occurred in 91% of patients with leg blood flow > or = 40 ml/min, in 18% with leg flow 30-39 ml/min and in 11% with leg flow < 30 ml/min. Complete relief of pain for at least 6 weeks occurred in 92% of patients in whose limbs the blood flow on day 8 was greater than 50 ml/min but only in 6% with blood flow less than 50 ml/min. These results indicate that iloprost increases leg blood flow and that patients likely to respond can be identified from the baseline air plethysmographic measurement of leg blood flow.

摘要

42条肢体出现缺血性静息痛且踝压等于或低于50 mmHg的34例患者接受了合成前列环素（伊洛前列素）静脉输注治疗，为期8天。在治疗前、治疗第4天和第8天，采用空气体积描记法测量腿部血流。腿部血流≥40 ml/min的患者中，91%的患者疼痛完全缓解至少6周；腿部血流为30 - 39 ml/min的患者中，18%的患者疼痛完全缓解至少6周；腿部血流<30 ml/min的患者中，11%的患者疼痛完全缓解至少6周。在第8天肢体血流大于50 ml/min的患者中，92%的患者疼痛完全缓解至少6周，但在血流小于50 ml/min的患者中，只有6%的患者疼痛完全缓解至少6周。这些结果表明，伊洛前列素可增加腿部血流，并且可以通过基线空气体积描记法测量的腿部血流来识别可能有反应的患者。