Whitley B D, Ferguson J W, Harris A J, Kardos T B
Department of Oral Medicine, Faculty of Dentistry University of Otago, Dunedin, New Zealand.
Int J Oral Maxillofac Surg. 1992 Feb;21(1):54-8. doi: 10.1016/s0901-5027(05)80455-2.
Based on the clinical observation that pain is experienced during parotid gland surgery under local anaesthesia, the presence of the sensory neuropeptide substance P (SP) was sought. Using a polyclonal antibody, the presence of SP was demonstrated by an indirect immunofluorescence technique, with rat parotid gland and spinal cord serving as controls. SP-containing neuronal elements occurred around acini, blood vessels and ducts. It is suggested that some of the SP-immunoreactive elements are the unmyelinated and thinly myelinated small diameter (A delta and C) fibres, which are regarded as the peripheral receptors for nociceptive information.
基于在局部麻醉下腮腺手术期间会感到疼痛这一临床观察，研究人员探寻了感觉神经肽P物质（SP）的存在情况。使用一种多克隆抗体，通过间接免疫荧光技术证实了SP的存在，以大鼠腮腺和脊髓作为对照。含SP的神经元成分出现在腺泡、血管和导管周围。有人提出，一些SP免疫反应性成分是无髓鞘和薄髓鞘的小直径（Aδ和C）纤维，它们被视为伤害性信息的外周感受器。
