REYN A, BENTZON M W
Bull World Health Organ. 1961;24(3):333-42.
The decreased sensitivity to penicillin of Neisseria gonorrhoeae has been a cause of concern during recent years. About 25% of strains sent in for routine diagnosis to the Statens Seruminstitut in 1957 were found to require roughly 20 times as much penicillin to inhibit development completely as was required for strains isolated in 1944. The stability of this reduced sensitivity to penicillin was studied in 20 strains which were subcultured daily on medium without penicillin. A comparison was also made between the sensitivity levels to penicillin and streptomycin for 1957 and 1958. A phenomenon possibly resulting from penicillin therapy of gonorrhoea was noted by the authors in June 1957, when they recorded the appearance of atypical strains having special growth requirements, low viability and weak or absent glucose-fermentation. The incidence, serology and sensitivity to antibiotics of these atypical strains were examined; further research on their different behaviour in response to changes in medium, as compared with that of typical strains, may give rise to some interesting findings.
近年来，淋病奈瑟菌对青霉素敏感性降低一直令人担忧。1957年送往丹麦国家血清研究所进行常规诊断的菌株中，约25%被发现抑制其完全生长所需的青霉素量约为1944年分离菌株所需量的20倍。在20株每天在不含青霉素的培养基上进行传代培养的菌株中研究了这种对青霉素敏感性降低的稳定性。还对1957年和1958年菌株对青霉素和链霉素的敏感性水平进行了比较。作者在1957年6月注意到一种可能由淋病青霉素治疗导致的现象，当时他们记录到出现了具有特殊生长需求、低活力以及弱或无葡萄糖发酵能力的非典型菌株。对这些非典型菌株的发生率、血清学及对抗生素的敏感性进行了检查；与典型菌株相比，进一步研究它们在培养基变化时的不同行为可能会产生一些有趣的发现。
