Xu X J, Wiesenfeld-Hallin Z
Department of Clinical Physiology, Karolinska Institute, Huddinge University Hospital, Sweden.
Acta Physiol Scand. 1992 Feb;144(2):163-8. doi: 10.1111/j.1748-1716.1992.tb09281.x.
The neuropeptide neurokinin A was injected intrathecally and its effect on the spinal nociceptive flexor reflex was examined. The reflex, which was evoked by electrical, thermal or mechanical stimulation of the foot and was recorded from the ipsilateral hamstring muscles, was substantially facilitated by 7 pmol intrathecally injected neurokinin A. The facilitatory effect of neurokinin A to thermal stimulation was, however, significantly stronger than to electrical or mechanical stimuli. Furthermore, co-administration of neurokinin A with substance P induced a significant synergistic facilitation of the reflex. It is suggested that neurokinin A, like substance P, may be released in association with activation of polymodal C-nociceptors.
将神经肽神经激肽A鞘内注射，并检测其对脊髓伤害性屈肌反射的影响。该反射由足部的电刺激、热刺激或机械刺激诱发，从同侧腘绳肌记录，鞘内注射7 pmol神经激肽A可显著增强该反射。然而，神经激肽A对热刺激的促进作用明显强于对电刺激或机械刺激的作用。此外，神经激肽A与P物质共同给药可显著协同增强该反射。提示神经激肽A可能与P物质一样，在多模式C伤害感受器激活时释放。
