Wiesenfeld-Hallin Z, Villar M J, Hökfelt T
Department of Clinical Neurophysiology and Physiology, Huddinge University Hospital, Sweden.
Exp Brain Res. 1988;71(3):663-6. doi: 10.1007/BF00248760.
The neuropeptide galanin (GAL) was injected intrathecally (i.t.) in decerebrate, spinalized, unanesthetized rats and its effect on the nocifensive flexor reflex was examined. The reflex, which was evoked by intense mechanical or thermal stimulation of the foot, was recorded from the ipsilateral hamstring muscles. I.t. GAL increased reflex excitability significantly more to thermal than to mechanical stimuli. It is suggested that GAL, which is present in sensory fibers that innervate the skin, is released by the central terminals of cutaneous afferents that are much more sensitive to thermal than to mechanical stimuli.
将神经肽甘丙肽（GAL）鞘内注射到去大脑、脊髓横断、未麻醉的大鼠体内，并检测其对伤害性屈肌反射的影响。通过对足部进行强烈的机械或热刺激诱发该反射，从同侧腘绳肌记录反射情况。鞘内注射GAL后，热刺激引起的反射兴奋性显著高于机械刺激。这表明，存在于支配皮肤的感觉纤维中的GAL，由对热刺激比对机械刺激更敏感的皮肤传入神经的中枢终末释放。
