免疫细胞损伤研究。I. 抗体和补体的细胞毒性作用。
Studies on immune cellular injury. I. Cytotoxic effects of antibody and complement.
作者信息
ROSS A, LEPOW I H
出版信息
J Exp Med. 1960 Dec 1;112(6):1085-106. doi: 10.1084/jem.112.6.1085.
Abstract
A model system for the investigation of immune cellular injury in primary isolates of a fixed-tissue cell of human origin has been described, using metabolism-inhibition and uptake of trypan blue as independent criteria of cytoxicity. Cytotoxic effects on human amnion cells were produced by the combination of specific rabbit antibody and factors in normal human serum which were indistinguishable from the components of hemolytic complement and calcium and magnesium ions. The data have been discussed in relation to the apparent multiplicity of serologic systems which can effect cellular injury. The nature of the cell and the source of antibody or normal serum constituents have been emphasized as factors which may influence the experimental selection of a given humoral mechanism.
摘要
已经描述了一种用于研究人类来源固定组织细胞原代分离物中免疫细胞损伤的模型系统，该系统使用代谢抑制和台盼蓝摄取作为细胞毒性的独立标准。特异性兔抗体与正常人血清中的因子结合，对人羊膜细胞产生细胞毒性作用，这些因子与溶血补体成分以及钙和镁离子无法区分。已结合可能影响细胞损伤的血清学系统的明显多样性对这些数据进行了讨论。细胞的性质以及抗体或正常血清成分的来源已被强调为可能影响给定体液机制实验选择的因素。
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