Immunohistochemical staining patterns of benign breast biopsies by 323/A3 and Ca1 monoclonal antibodies related to epidemiological and radiological risk criteria.

Monoclonal antibodies 323/A3 and Ca1 have been suggested as markers of breast cancer risk in benign breast disease. We have studied the staining profiles in benign biopsies of 323/A3 and Ca1 in 146 patients. We then compared the staining patterns grouped according to whether the patients were at "high or low" risk of breast cancer by conventional epidemiological or radiological criteria. The results show that the staining profiles are similar between risk groups and that on the risk criteria used in this study 323/A3 and Ca1 will not distinguish patients at risk of developing breast cancer.