King E B, Chew K L, Petrakis N L, Ernster V L
J Natl Cancer Inst. 1983 Dec;71(6):1115-21.
The association of abnormal nonmalignant cells in nipple aspirate fluid (NAF) and atypical proliferative disease (APD) of breast ducts was examined in the presence and absence of breast cancer in 134 patients. A high frequency of NAF samples with cellular abnormalities (atypical hyperplasia) was found when APD occurred with either breast cancer (70%) or benign breast biopsy specimens (54%). APD was present in 27 malignant cases (80%) and in 39 benign cases (39%). Inasmuch as APD may represent an intermediate step in the malignant transformation of duct epithelium, the cytologic examination of NAF offers a new approach with which to study the spectrum of breast cancer precursors and to assist in identifying women at risk for breast cancer.
在134例患者中，研究了乳头抽吸液（NAF）中异常非恶性细胞与乳腺导管非典型增生性疾病（APD）之间的关联，这些患者有的患有乳腺癌，有的未患乳腺癌。当APD与乳腺癌（70%）或良性乳腺活检标本（54%）同时出现时，发现NAF样本中细胞异常（非典型增生）的频率很高。27例恶性病例（80%）和39例良性病例（39%）中存在APD。由于APD可能代表导管上皮恶性转化的中间步骤，NAF的细胞学检查提供了一种新方法，可用于研究乳腺癌前体的范围，并有助于识别有乳腺癌风险的女性。
