一种导致新生小鼠胸腺坏死的新型小鼠病毒。
A new mouse virus causing necrosis of the thymus in newborn mice.
作者信息
ROWE W P, CAPPS W I
出版信息
J Exp Med. 1961 May 1;113(5):831-44. doi: 10.1084/jem.113.5.831.
Abstract
A new mouse virus has been recovered from laboratory and wild mice. The agent induces a non-fatal disease in infant mice, characterized by acute massive necrosis of the thymic medulla and cortex, granulomatous reaction, and subsequent restoration of essentially normal architecture with scarring. Intranuclear inclusion bodies are produced. Virus may persist in tissues of convalescent mice for many months. Electron micrographs of acutely infected thymuses showed nuclear and cytoplasmic karyoannular particles and masses of parallel fibrils in nuclei.
摘要
一种新的小鼠病毒已从实验室小鼠和野生小鼠体内分离出来。该病原体可在幼鼠中引发一种非致命性疾病，其特征为胸腺髓质和皮质急性大量坏死、肉芽肿反应，随后基本正常的结构得以恢复并伴有瘢痕形成。会产生核内包涵体。病毒可能在康复小鼠的组织中持续存在数月。急性感染胸腺的电子显微镜照片显示，细胞核和细胞质中有核环颗粒以及细胞核内的平行纤维束。
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