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Amplification of the N-myc gene in human neuroblastomas: tandemly repeated amplicons within homogeneously staining regions on different chromosomes with the retention of single copy gene at the resident site.

作者信息

Amler L C, Shibasaki Y, Savelyeva L, Schwab M

机构信息

Institut für Experimentelle Pathologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany.

出版信息

Mutat Res. 1992 May;276(3):291-7. doi: 10.1016/0165-1110(92)90015-2.

DOI:10.1016/0165-1110(92)90015-2
PMID:1374521
Abstract
摘要

相似文献

1
Amplification of the N-myc gene in human neuroblastomas: tandemly repeated amplicons within homogeneously staining regions on different chromosomes with the retention of single copy gene at the resident site.人神经母细胞瘤中N-myc基因的扩增：不同染色体上均匀染色区域内的串联重复扩增子，且在驻留位点保留单拷贝基因。
Mutat Res. 1992 May;276(3):291-7. doi: 10.1016/0165-1110(92)90015-2.
2
Megabase-scale analysis of the origin of N-myc amplicons in human neuroblastomas.人类神经母细胞瘤中N-myc扩增子起源的兆碱基规模分析。
Nucleic Acids Res. 1994 Jan 25;22(2):187-93. doi: 10.1093/nar/22.2.187.
3
Duplication of N-MYC at its resident site 2p24 may be a mechanism of activation alternative to amplification in human neuroblastoma cells.
Cancer Res. 1995 Aug 15;55(16):3471-4.
4
Cloning and physical mapping of DNA sequences encompassing a region in N-myc amplicons of a human neuroblastoma cell line.包含人类神经母细胞瘤细胞系N - myc扩增子区域的DNA序列的克隆与物理图谱构建。
Nucleic Acids Res. 1991 Dec 25;19(24):6887-94. doi: 10.1093/nar/19.24.6887.
5
Chromosomal localization of amplified N-myc in neuroblastoma cells using a biotinylated probe.
Cancer Genet Cytogenet. 1992 Jan;58(1):55-9. doi: 10.1016/0165-4608(92)90134-t.
6
MYCN amplification and 17q in neuroblastoma: evidence for structural association.神经母细胞瘤中的MYCN扩增与17号染色体长臂：结构关联的证据
Genes Chromosomes Cancer. 2001 Jan;30(1):87-90.
7
Multiple amplicons of discrete sizes encompassing N-myc in neuroblastoma cells evolve through differential recombination from a large precursor DNA.
Oncogene. 1992 Apr;7(4):807-9.
8
MYCN is retained in single copy at chromosome 2 band p23-24 during amplification in human neuroblastoma cells.在人类神经母细胞瘤细胞扩增过程中，MYCN在2号染色体p23 - 24带以单拷贝形式保留。
Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5523-7. doi: 10.1073/pnas.91.12.5523.
9
Detection of MYCN amplification in three neuroblastoma cell lines by non-radioactive chromosomal in situ hybridization.通过非放射性染色体原位杂交检测三种神经母细胞瘤细胞系中的MYCN扩增。
Cancer Genet Cytogenet. 1992 Apr;59(2):128-34. doi: 10.1016/0165-4608(92)90206-n.
10
Sensitive and reliable detection of genomic imbalances in human neuroblastomas using comparative genomic hybridisation analysis.利用比较基因组杂交分析对人类神经母细胞瘤中的基因组失衡进行灵敏且可靠的检测。
Eur J Cancer. 1997 Oct;33(12):1979-82. doi: 10.1016/s0959-8049(97)00289-x.

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Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution.人类癌症扩增子中体细胞基因组重排的序列水平分辨率架构
Genome Res. 2007 Sep;17(9):1296-303. doi: 10.1101/gr.6522707. Epub 2007 Aug 3.
2
Neuroblastoma tumour genetics: clinical and biological aspects.神经母细胞瘤肿瘤遗传学：临床与生物学方面
J Clin Pathol. 2001 Dec;54(12):897-910. doi: 10.1136/jcp.54.12.897.
3
MYCN gene amplification. Identification of cell populations containing double minutes and homogeneously staining regions in neuroblastoma tumors.
MYCN基因扩增。神经母细胞瘤肿瘤中含双微体和均匀染色区细胞群的鉴定。
Am J Pathol. 1999 Nov;155(5):1439-43. doi: 10.1016/S0002-9440(10)65457-0.
4
Chemically induced changes in the spectrum of amplifications of the human minisatellite MS1 integrated in chromosome III of a haploid yeast strain.
Mol Gen Genet. 1994 Jan;242(2):137-44. doi: 10.1007/BF00391006.
5
Hairpin structures are the primary amplification products: a novel mechanism for generation of inverted repeats during gene amplification.发夹结构是主要的扩增产物：基因扩增过程中产生反向重复序列的一种新机制。
Mol Cell Biol. 1994 Dec;14(12):7782-91. doi: 10.1128/mcb.14.12.7782-7791.1994.
6
Chromosome breakage at a major fragile site associated with P-glycoprotein gene amplification in multidrug-resistant CHO cells.在多药耐药的中国仓鼠卵巢细胞中，与P-糖蛋白基因扩增相关的一个主要脆性位点处的染色体断裂。
Mol Cell Biol. 1994 Aug;14(8):5202-11. doi: 10.1128/mcb.14.8.5202-5211.1994.