SANFORD J P, BARNETT J A, GOTT C
J Exp Med. 1960 Jul 1;112(1):97-105. doi: 10.1084/jem.112.1.97.
These experiments have demonstrated that liver glycogen may rise or fall after endotoxin administration, depending upon the antecedent diet and that total adrenalectomy followed by corticosteroid replacement abolishes the glycogenolytic effect of sublethal doses of endotoxin. It is concluded that the derangements of carbohydrate metabolism observed following the administration of sublethal quantities of bacterial endotoxin represent, not a direct hepatotoxic effect of endotoxin, but rather the passive consequence of epinephrine release.
这些实验表明，给予内毒素后肝糖原可能上升或下降，这取决于先前的饮食情况，并且全肾上腺切除术后给予皮质类固醇替代物可消除亚致死剂量内毒素的糖原分解作用。得出的结论是，给予亚致死量细菌内毒素后观察到的碳水化合物代谢紊乱并非内毒素的直接肝毒性作用，而是肾上腺素释放的被动结果。
