甲状腺自身免疫与甲状腺圆细胞浸润的关系。
The relation of thyroid auto-immunity to round-celled infiltration of the thyroid gland.
作者信息
SCHADE R O, OWEN S G, SMART G A, HALL R
出版信息
J Clin Pathol. 1960 Nov;13(6):499-501. doi: 10.1136/jcp.13.6.499.
Abstract
The relationship between thyroid auto-immunity and the presence of lymphocytes in the thyroid gland has been analysed in patients with Graves' disease, toxic adenoma, and non-toxic nodular goitre. In all these conditions circulating antibody to thyroglobulin was significantly associated with lymphocytic infiltration. No similar correlation was established in the case of the complement-fixing antibody.Complement-fixing antibody was significantly commoner in Graves' disease (diffuse thyrotoxic goitre) than in toxic adenoma and non-toxic nodular goitre. Circulating thyroglobulin antibody probably originates from lymphoid tissue within and around the thyroid gland itself. Overactivity of pituitary thyrotropin may favour immunization to the intracellular (complementfixing) antigen.
摘要
对患有格雷夫斯病、毒性腺瘤和非毒性结节性甲状腺肿的患者，分析了甲状腺自身免疫与甲状腺内淋巴细胞存在情况之间的关系。在所有这些病症中，甲状腺球蛋白循环抗体与淋巴细胞浸润显著相关。在补体结合抗体方面未建立类似的相关性。补体结合抗体在格雷夫斯病（弥漫性甲状腺毒性肿）中比在毒性腺瘤和非毒性结节性甲状腺肿中显著更常见。甲状腺球蛋白循环抗体可能源自甲状腺自身及其周围的淋巴组织。垂体促甲状腺激素活性过高可能有利于针对细胞内（补体结合）抗原的免疫反应。
相似文献
1
The relation of thyroid auto-immunity to round-celled infiltration of the thyroid gland.甲状腺自身免疫与甲状腺圆细胞浸润的关系。
J Clin Pathol. 1960 Nov;13(6):499-501. doi: 10.1136/jcp.13.6.499.
2
Thyrotropin-producing pituitary adenoma simultaneously existing with Graves' disease: a case report.促甲状腺激素分泌型垂体腺瘤与格雷夫斯病同时存在：一例报告
J Med Case Rep. 2017 Jan 6;11(1):9. doi: 10.1186/s13256-016-1172-4.
3
TSH-receptor autoantibodies - differentiation of hyperthyroidism between Graves' disease and toxic multinodular goitre.促甲状腺激素受体自身抗体——格雷夫斯病与毒性多结节性甲状腺肿所致甲状腺功能亢进的鉴别
Exp Clin Endocrinol Diabetes. 2004 Apr;112(4):171-4. doi: 10.1055/s-2004-817930.
4
Thyrotropin receptor antibodies in hypothyroid Graves' disease.甲状腺功能减退型格雷夫斯病中的促甲状腺激素受体抗体
J Clin Endocrinol Metab. 1993 Feb;76(2):504-8. doi: 10.1210/jcem.76.2.8094394.
5
Correlation of microsomal antibodies with the intensity of the intrathyroidal autoimmune process in Graves' disease.微粒体抗体与格雷夫斯病甲状腺内自身免疫过程强度的相关性。
J Clin Endocrinol Metab. 1993 Oct;77(4):939-43. doi: 10.1210/jcem.77.4.8408468.
6
The link between Graves' disease and Hashimoto's thyroiditis: a role for regulatory T cells.格雷夫斯病与桥本甲状腺炎之间的联系：调节性T细胞的作用。
Endocrinology. 2007 Dec;148(12):5724-33. doi: 10.1210/en.2007-1024. Epub 2007 Sep 6.
7
Antibodies to the thyroid gland and to the thyrotrophin receptor in African and Indian thyrotoxic patients.非洲和印度甲状腺功能亢进患者体内针对甲状腺及促甲状腺激素受体的抗体
Postgrad Med J. 1986 Sep;62(731):837-9. doi: 10.1136/pgmj.62.731.837.
8
[The relationship between serum thyroid autoantibodies, iodine intake, development and prognosis of Graves' disease].[血清甲状腺自身抗体、碘摄入量与Graves病的发生发展及预后的关系]
Zhonghua Nei Ke Za Zhi. 2006 Feb;45(2):95-9.
9
[A study of biological and histological criteria of thyroid autoimmunity in diffuse goiters with hyperthyroidism].[弥漫性甲状腺肿伴甲状腺功能亢进症中甲状腺自身免疫的生物学和组织学标准研究]
Ann Endocrinol (Paris). 1997;58(5):393-8.
10
Appearance of anti TSH-receptor antibodies and clinical Graves' disease after radioiodine therapy for hyperfunctioning thyroid adenoma.高功能甲状腺腺瘤放射性碘治疗后抗促甲状腺激素受体抗体的出现及临床Graves病
J Endocrinol Invest. 1999 Feb;22(2):147-50. doi: 10.1007/BF03350896.
引用本文的文献
1
Correlation of fine needle aspiration cytology findings with thyroid function test in cases of lymphocytic thyroiditis.淋巴细胞性甲状腺炎病例中细针穿刺细胞学检查结果与甲状腺功能检查的相关性
J Thyroid Res. 2014;2014:430510. doi: 10.1155/2014/430510. Epub 2014 Apr 6.
2
THYROTOXICOSIS TREATED BY SURGERY OR IODINE-131. WITH SPECIAL REFERENCE TO DEVELOPMENT OF HYPOTHYROIDISM.手术或碘 - 131治疗甲状腺毒症。特别提及甲状腺功能减退症的发生。
Br Med J. 1964 Apr 18;1(5389):1005-10. doi: 10.1136/bmj.1.5389.1005.
3
Sarcoidosis and hyperthyroidism.结节病与甲状腺功能亢进症。
Proc R Soc Med. 1963 Jul;56(7):612-3. doi: 10.1177/003591576305600730.
4
The incidence of thyroglobulin antibodies and thyroid enlargement in a general practice in north-east England.英格兰东北部一家普通诊所中甲状腺球蛋白抗体和甲状腺肿大的发病率。
Clin Exp Immunol. 1966 Jul;1(3):277-84.
5
Thyrotoxicosis in the African: clinical and immunological observations.非洲人的甲状腺毒症：临床与免疫学观察
Br Med J. 1971 Jun 19;2(5763):679-81. doi: 10.1136/bmj.2.5763.679.
6
Experimental studies related to autoimmunity in myasthenia gravis.与重症肌无力自身免疫相关的实验研究。
J Neurol Neurosurg Psychiatry. 1969 Aug;32(4):281-9. doi: 10.1136/jnnp.32.4.281.
7
Pathogenetic relevance of HLA class II expressing thyroid follicular cells in nontoxic Goiter and in Graves' disease.表达HLA-II类分子的甲状腺滤泡细胞在非毒性甲状腺肿和格雷夫斯病中的发病机制相关性
J Clin Invest. 1988 May;81(5):1608-14. doi: 10.1172/JCI113495.
本文引用的文献
1
The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera.蛋白质在经单宁酸处理的红细胞上的吸附以及随后抗蛋白质血清引起的血细胞凝集。
J Exp Med. 1951 Feb;93(2):107-20. doi: 10.1084/jem.93.2.107.
2
Cytotoxic effects of Hashimoto serum on human thyroid cells in tissue culture.桥本血清对组织培养中人类甲状腺细胞的细胞毒性作用。
Lancet. 1959 Aug 29;2(7096):214-6. doi: 10.1016/s0140-6736(59)90161-8.
3
Cytoplasmic localization of "complement-fixing" auto-antigen in human thyroid epithelium.人甲状腺上皮中“补体结合”自身抗原的细胞质定位
Br J Exp Pathol. 1959 Dec;40(6):583-8.
4
Thyroid antibodies and thyroiditis.甲状腺抗体与甲状腺炎。
Postgrad Med J. 1960 Jul;36(417):442-5. doi: 10.1136/pgmj.36.417.442.
5
Investigations of thyroid antigens reacting with Hashimoto sera; evidence for an antigen other than thyroglobulin.与桥本氏血清发生反应的甲状腺抗原研究；存在除甲状腺球蛋白之外的一种抗原的证据。
Lancet. 1959 Mar 28;1(7074):648-52. doi: 10.1016/s0140-6736(59)92401-8.
6
Complement-fixing antithyroid antibodies in hospital patients with asymptomatic thyroid lesions.医院中患有无症状甲状腺病变患者的补体结合性抗甲状腺抗体
J Pathol Bacteriol. 1959 Apr;77(2):389-400. doi: 10.1002/path.1700770208.
7
Thyroid antibodies in myxoedema.黏液性水肿中的甲状腺抗体。
Lancet. 1958 Nov 15;2(7055):1034-6. doi: 10.1016/s0140-6736(58)90531-2.
8
Human autoimmune thyroiditis: serological studies.人类自身免疫性甲状腺炎：血清学研究。
Lancet. 1958 Nov 15;2(7055):1027-33. doi: 10.1016/s0140-6736(58)90530-0.
9
Precipitating and complement-fixing antibodies in Hashimoto's disease.桥本氏病中的沉淀抗体和补体结合抗体。
Proc R Soc Med. 1957 Nov;50(11):961-2.
Zotero 插件