非洲人的甲状腺毒症：临床与免疫学观察
Thyrotoxicosis in the African: clinical and immunological observations.
作者信息
McGill P E
出版信息
Br Med J. 1971 Jun 19;2(5763):679-81. doi: 10.1136/bmj.2.5763.679.
Abstract
The clinical manifestations of thyrotoxicosis are described in 20 African patients with toxic diffuse goitre (Graves's disease) and five with toxic nodular goitre. Antibody to thyroglubulin was detected in the serum of one patient and antibody to thyroid microsomes in four patients. Round-cell infiltration of the thyroid gland was present in 27% of 30 African thyrotoxic patients and 73% of appropriately matched Caucasian patients. It is suggested that the low incidence of thyrotoxicosis in the African race is related to an inability to form thyroid autoantibodies.
摘要
对20例患有毒性弥漫性甲状腺肿（格雷夫斯病）的非洲患者和5例患有毒性结节性甲状腺肿的患者的甲状腺毒症临床表现进行了描述。在1例患者的血清中检测到甲状腺球蛋白抗体，在4例患者中检测到甲状腺微粒体抗体。30例非洲甲状腺毒症患者中有27%以及匹配的白种人患者中有73%存在甲状腺的淋巴细胞浸润。有人提出，非洲人种中甲状腺毒症的低发病率与无法形成甲状腺自身抗体有关。
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本文引用的文献
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Cytoplasmic localization of "complement-fixing" auto-antigen in human thyroid epithelium.人甲状腺上皮中“补体结合”自身抗原的细胞质定位
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SCREENING TESTS FOR THYROID DISEASE AND RHEUMATOID ARTHRITIS AS A ROUTINE HOSPITAL PROCEDURE.作为医院常规检查项目的甲状腺疾病和类风湿关节炎筛查测试。
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AUTOIMMUNITY AND THYROTOXICOSIS.自身免疫与甲状腺毒症
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