（2'-5'）寡腺苷酸与抗逆转录病毒感染的细胞内免疫
(2'-5')Oligoadenylate and intracellular immunity against retrovirus infection.
作者信息
Schröder H C, Suhadolnik R J, Pfleiderer W, Charubala R, Müller W E
机构信息
Institut für Physiologische Chemie, Abteilung Angewandte Molekularbiologie Johannes Gutenberg-Universität, Mainz, Fed. Rep. Germany.
出版信息
Int J Biochem. 1992;24(1):55-63. doi: 10.1016/0020-711x(92)90229-t.
PMID:1374726
Abstract
- The double-stranded RNA-dependent 2',5'-oligoadenylate (2-5A) synthetase/ribonuclease L (RNase L) system plays an essential role in the establishment of the antiviral state of a cell exposed to virus infection. 2. Until recently, the application of 2-5A derivatives to reinforce this system seemed to be limited mainly due to the low specificity of RNase L for viral RNA. 3. Two new strategies have been developed which yield a selective antiviral effect of 2-5As at least against human immunodeficiency virus-1 (HIV-1) infection: (i) an "intracellular immunization" approach using 2-5A synthetase cDNA linked to HIV trans-acting response element (TAR) and (ii) inhibition of retroviral reverse transcriptase activity by 2-5A analogues.
摘要
- 双链RNA依赖性2′,5′-寡腺苷酸（2-5A）合成酶/核糖核酸酶L（RNase L）系统在细胞建立抗病毒状态以应对病毒感染过程中发挥着至关重要的作用。2. 直到最近，2-5A衍生物用于强化该系统的应用似乎主要受到限制，这主要是由于RNase L对病毒RNA的特异性较低。3. 已经开发出两种新策略，它们至少对人类免疫缺陷病毒1型（HIV-1）感染产生2-5A的选择性抗病毒作用：（i）一种“细胞内免疫”方法，使用与HIV反式作用应答元件（TAR）相连的2-5A合成酶cDNA，以及（ii）通过2-5A类似物抑制逆转录病毒逆转录酶活性。
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