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大鼠佐剂性单关节炎模型中，支配背根神经节的P物质和降钙素基因相关肽增加，但生长抑素含量未增加。

Increase in substance P and CGRP, but not somatostatin content of innervating dorsal root ganglia in adjuvant monoarthritis in the rat.

作者信息

Smith G D, Harmar A J, McQueen D S, Seckl J R

机构信息

MRC Brain Metabolism Unit, Edinburgh, UK.

出版信息

Neurosci Lett. 1992 Mar 30;137(2):257-60. doi: 10.1016/0304-3940(92)90417-6.

DOI:10.1016/0304-3940(92)90417-6
PMID:1374870
Abstract

Neuropeptides, synthesized in dorsal root ganglia (DRG), are implicated in nociception and neurogenic inflammation. Alterations in DRG neuropeptide levels have been described in polyarthritic rats, but these models are associated with widespread systemic disease. Using mild adjuvant-mediated monoarthritis of the left carpal joint we found significant increases in substance P (+69%) and calcitonin gene-related peptide (CGRP; +204+), but not somatostatin in ipsilateral C6/7 DRG. Peptide levels in contralateral DRG and other ipsilateral DRG were unaltered. Substance P and CGRP in DRG may be of importance in the pathogenesis and maintenance of adjuvant arthritis.

摘要

在背根神经节（DRG）中合成的神经肽与伤害感受和神经源性炎症有关。在多关节炎大鼠中已描述了DRG神经肽水平的改变，但这些模型与广泛的全身性疾病有关。通过使用轻度佐剂介导的左腕关节单关节炎，我们发现同侧C6/7 DRG中的P物质（增加69%）和降钙素基因相关肽（CGRP；增加204%）显著增加，但生长抑素未增加。对侧DRG和其他同侧DRG中的肽水平未改变。DRG中的P物质和CGRP可能在佐剂性关节炎的发病机制和维持中起重要作用。

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