Smith G D, Seckl J R, Harmar A J
MRC Brain Metabolism Unit, Royal Edinburgh Hospital, UK.
Neurosci Lett. 1993 Apr 16;153(1):5-8. doi: 10.1016/0304-3940(93)90063-q.
We have used sensitive and specific radioimmunoassays to examine the differential distributions of three neuropeptides, substance P (SP), calcitonin gene-related peptide (CGRP) and somatostatin (SST), in dorsal root ganglia (DRG) from levels C1 to L6 of the spinal column. SP and CGRP content both varied in proportion to ganglion wet weight, with greatest levels in cervical and lumbar DRG. By contrast, SST content showed a distinct distribution, with maximum levels in rostral, cervical DRG. We speculate that the distribution of these neuropeptides may be due to the influence of target-derived neurotrophic factors, and may underlie the particular sensitivity of the hind limbs to adjuvant arthritis in the rat.
我们运用灵敏且特异的放射免疫分析法，检测了三种神经肽，即P物质（SP）、降钙素基因相关肽（CGRP）和生长抑素（SST），在脊柱C1至L6节段背根神经节（DRG）中的差异分布。SP和CGRP的含量均与神经节湿重成比例变化，在颈段和腰段DRG中含量最高。相比之下，SST含量呈现出独特的分布，在头端颈段DRG中含量最高。我们推测，这些神经肽的分布可能是由于靶源性神经营养因子的影响，并且可能是大鼠后肢对佐剂性关节炎具有特殊敏感性的基础。
