Puissant A
Rev Stomatol Chir Maxillofac. 1976 Jul-Aug;77(5):735-9.
Acute epidermal necrosis is an exceptionally serious condition whose onset, which is sometimes preceded by a few prodomes, is marked by an eruption mainly around the orifices and rapidly extending to the whole of the tegument. Epidermal necrosis results in extensive shedding of the skin and within the space of a few hours gives the patient the appearance of having been scalded. In adults, drugs and in particular certain combinations of drugs, are responsible; the drugs mainly involved are the sulfonamides, especially delayed action sulfonamides, derivatives of butazolidine, Barbiturates, Phenindione and Penicillin. In children, on the other hand, acute epidermal necrosis is usually secondary to infection by a phase 2 coagulase positive staphylococcus aureus, this staphylococcus secreting an exotoxin which appears to act by breaking up the desmosomes. Treatment mainly consists of emergency resuscitation.
急性表皮坏死是一种极其严重的病症，其发病有时在出现一些前驱症状之后，主要表现为孔窍周围发疹，并迅速蔓延至整个体表。表皮坏死导致皮肤大量脱落，在数小时内会使患者呈现出被烫伤的外观。在成人中，药物尤其是某些药物组合是病因；主要涉及的药物有磺胺类药物，特别是长效磺胺类、保泰松衍生物、巴比妥类、苯茚二酮和青霉素。另一方面，在儿童中，急性表皮坏死通常继发于2型凝固酶阳性金黄色葡萄球菌感染，这种葡萄球菌分泌一种外毒素，似乎通过破坏桥粒起作用。治疗主要包括紧急复苏。
