[亨廷顿舞蹈病中生物胺的脑脊液代谢]
[Cerebrospinal fluid metabolism of biogenic amines in Huntington chorea].
作者信息
Loeb C, Roccatagliata G, Albano C, Lamedica G, Abbruzzese G, Canini S
出版信息
Schweiz Arch Neurol Neurochir Psychiatr. 1976;119(2):333-42.
PMID:137520
Abstract
CSF metabolites of dopamine (HVA), norepinephrine (MHPG) and serotonine (5HIAA) in 9 patients affected by Huntington's Chorea before and after therapy with phenotiazine derivatives (Fluphenazine) have been studied. A close relationship seems to exist between therapeutical results and CSF HVA modifications: improvement of choreatic movements is associated with marked increase in CSF HVA values. Biochemical bases of Huntington's Chorea are discussed.
摘要
对9例患亨廷顿舞蹈症的患者在使用吩噻嗪衍生物（氟奋乃静）治疗前后脑脊液中多巴胺代谢物（高香草酸）、去甲肾上腺素（3-甲氧基-4-羟基苯乙二醇）和5-羟色胺（5-羟吲哚乙酸）进行了研究。治疗结果与脑脊液中高香草酸的变化之间似乎存在密切关系：舞蹈样动作的改善与脑脊液中高香草酸值的显著增加有关。本文讨论了亨廷顿舞蹈症的生化基础。
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