Barkley D S, Hardiwidjaja S, Menkes J H
Science. 1977 Jan 21;195(4275):314-6. doi: 10.1126/science.137525.
Huntington's disease is a hereditary, chronic, degenerative disease of the brain which is transmitted by an autosomal dominant gene. We have discovered that lymphocytes from patients with Huntington's disease respond to the presence of brain tissue from patients with the disease by producing migration inhibition factor, a correlate of the cellular immune response. Lymphocytes from donors without the disease do not respond to the diseased brain tissue, and lymphocytes from patients with Huntington's disease respond only rarely to brain tissue from donors without the disease.
亨廷顿舞蹈症是一种遗传性、慢性、进行性脑部疾病，由常染色体显性基因遗传。我们发现，亨廷顿舞蹈症患者的淋巴细胞会对患有该疾病患者的脑组织产生反应，分泌迁移抑制因子，这是细胞免疫反应的一个相关指标。未患该疾病的捐赠者的淋巴细胞对患病脑组织无反应，而亨廷顿舞蹈症患者的淋巴细胞对未患该疾病捐赠者的脑组织仅有极少反应。
