亨廷顿舞蹈症与白细胞黏附抑制（LAI）。
Huntington's disease and leucocyte adherence inhibition. (LAI).
作者信息
Hardiwidjaja S I, Morgan A, Ellison G W, Myers L W, Pierce W G, Barkley D S
出版信息
Clin Exp Immunol. 1981 Sep;45(3):583-9.
Abstract
Patients with Huntington's disease (HD) appear to possess a brain antigen not found in undiseased brain tissue. The tube leucocyte adherence inhibition (LAI) assay detects immunity to this putative antigen in individuals with Huntington's disease (82%), multiple sclerosis (48%), other neurological disease (17%) and no neurological disease (16%). The antigen-like activity can be extracted from HD brain with 3 M KCl and precipitated with 65–80% saturated ammonium sulphate.
摘要
患有亨廷顿舞蹈症（HD）的患者似乎拥有一种在未患病脑组织中未发现的脑抗原。试管白细胞黏附抑制（LAI）试验可检测出亨廷顿舞蹈症患者（82%）、多发性硬化症患者（48%）、其他神经疾病患者（17%）以及无神经疾病者（16%）对这种假定抗原的免疫反应。这种抗原样活性可用3M氯化钾从HD脑组织中提取出来，并用65 - 80%饱和度的硫酸铵沉淀。
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Properties of a brain-specific protein fraction which absorbs anti-neuronal antibodies in sera from patients with Huntington's disease.
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