Scott M G, Nahm M H
Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.
J Infect Dis. 1992 Jun;165 Suppl 1:S53-6. doi: 10.1093/infdis/165-supplement_1-s53.
The human antibody response to the capsular polysaccharide of Haemophilus influenzae type b (Hib) is a good model for examining human V region repertoires. While the VL repertoire of human antibodies to Hib polysaccharide is relatively simple and dominated by the product of a germline V kappa II gene named A2, at least five other VL genes can be expressed by some individuals. These include at least two V kappa I products and at least one V kappa III, one V kappa IV, and one V lambda product. The epitope recognized by a monoclonal anti-idiotype antibody is on the A2 V kappa II product.
人类对b型流感嗜血杆菌（Hib）荚膜多糖的抗体反应是研究人类V区库的一个良好模型。虽然人类针对Hib多糖的抗体VL库相对简单，且以一个名为A2的种系VκII基因的产物为主，但一些个体至少还能表达其他五个VL基因。这些基因包括至少两个VκI产物、至少一个VκIII、一个VκIV和一个Vλ产物。一种单克隆抗独特型抗体识别的表位位于A2 VκII产物上。
