Jiang H, Zhang S I, Pernis B
Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Science. 1992 May 22;256(5060):1213-5. doi: 10.1126/science.256.5060.1213.
The course of experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis, is affected by immunoregulatory T lymphocytes. When animals are immunized with encephalitogenic peptide of myelin basic protein and recover from the first episode of EAE, they become resistant to a second induction of this disease. Animals depleted of CD8+ T cells by antibody-mediated clearance were used to examine the role of CD8+ T cells in EAE. These cells were found to be major participants in the resistance to a second induction of EAE but were not essential for spontaneous recovery from the first episode of the disease.
实验性自身免疫性脑脊髓炎（EAE）是多发性硬化症的动物模型，其病程受免疫调节性T淋巴细胞影响。当动物用髓鞘碱性蛋白的致脑炎肽免疫并从EAE的首次发作中恢复后，它们对该疾病的二次诱导产生抗性。通过抗体介导的清除作用耗尽CD8 + T细胞的动物被用于研究CD8 + T细胞在EAE中的作用。发现这些细胞是抵抗EAE二次诱导的主要参与者，但对于从疾病的首次发作中自发恢复并非必不可少。
