Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.
Immunogenetics. 2023 Jun;75(3):269-282. doi: 10.1007/s00251-023-01293-w. Epub 2023 Jan 31.
Killer-cell immunoglobulin-like receptors (KIRs) are mainly expressed on natural killer (NK) cells and are key regulators of innate immune responses. NK cells are the first responders in the face of infection and help promote placentation during pregnancy; the importance of KIRs in these NK-mediated processes is well-established. However, mounting evidence suggests that KIRs also have a prominent and long-lasting effect on the adaptive immune system. Here, we review the evidence for the impact of KIRs on T cell responses with a focus on the clinical significance of this interaction.
杀伤细胞免疫球蛋白样受体（KIR）主要表达于自然杀伤（NK）细胞上，是先天免疫反应的关键调节因子。NK 细胞是感染发生时的第一道防线，有助于促进妊娠期间的胎盘形成；KIR 在这些 NK 介导的过程中的重要性已得到充分证实。然而，越来越多的证据表明，KIR 对适应性免疫系统也有显著且持久的影响。在这里，我们综述了 KIR 对 T 细胞反应的影响证据，重点关注这种相互作用的临床意义。
