Voltaire A, Beck O, Borg S
Department of Psychiatry, St. Görans Hospital, Karolinska Institute, Stockholm, Sweden.
Alcohol Clin Exp Res. 1992 Apr;16(2):281-5. doi: 10.1111/j.1530-0277.1992.tb01377.x.
Urinary 5-hydroxytryptophol (5-HTOL) is currently being evaluated as a marker of recent alcohol consumption. To compensate for urinary dilution, the molar ratio between 5-HTOL and 5-hydroxyindole-3-acetic acid (5-HIAA) is used. The 5-HTOL/5-HIAA ratio showed a satisfactory degree of individual stability when it was followed in a group of teetotallers for 1 month. The mean value of 5-HTOL/5-HIAA in a group of 69 persons abstaining from alcohol was 7.6 (pmoles 5-HTOL/nmoles 5-HIAA). Ninety-seven percent had values ranging from 4 to 17, with no value exceeding 20. A group of healthy volunteers were tested 12 hr after alcohol consumption and showed a dose-dependent and statistically significant elevation in the 5-HTOL/5-HIAA ratio. Four regular alcohol consumers who were followed during a period of 3 months of drinking had elevated values of the 5-HTOL/5-HIAA ratio in 60% of their urine samples. The present study indicates that urinary 5-HTOL/5-HIAA is a sensitive and reliable marker of recent alcohol consumption. We propose that a 5-HTOL/5-HIAA ratio greater than 20 (pmoles/nmoles) can be used to indicate recent alcohol consumption. This limit gives a low frequency of false positives; the statistical probability of having a value greater than 20 during abstinence from alcohol was calculated to be less than 0.001.
尿中5-羟色醇（5-HTOL）目前正被评估为近期饮酒的标志物。为补偿尿液稀释的影响，采用5-HTOL与5-羟吲哚-3-乙酸（5-HIAA）的摩尔比。在一组禁酒者中随访1个月时，5-HTOL/5-HIAA比值显示出令人满意的个体稳定性。69名戒酒者的5-HTOL/5-HIAA平均值为7.6（皮摩尔5-HTOL/纳摩尔5-HIAA）。97%的人的值在4至17之间，无值超过20。一组健康志愿者在饮酒12小时后接受测试，结果显示5-HTOL/5-HIAA比值呈剂量依赖性升高且具有统计学意义。在3个月饮酒期内对4名经常饮酒者进行随访，其60%的尿液样本中5-HTOL/5-HIAA比值升高。本研究表明，尿中5-HTOL/5-HIAA是近期饮酒的敏感且可靠的标志物。我们建议，5-HTOL/5-HIAA比值大于20（皮摩尔/纳摩尔）可用于指示近期饮酒。此限值产生假阳性的频率较低；计算得出在戒酒期间值大于20的统计概率小于0.001。
