血清乳酸脱氢酶同工酶1和肿瘤体积是转移性睾丸生殖细胞肿瘤治疗反应的指标和预后的预测因素。

Serum lactate dehydrogenase isoenzyme 1 and tumour volume are indicators of response to treatment and predictors of prognosis in metastatic testicular germ cell tumours.

作者信息

von Eyben F E, Blaabjerg O, Madsen E L, Petersen P H, Smith-Sivertsen C, Gullberg B

机构信息

Department of Internal Medicine, Central Hospital, Nykøbing Falster, Denmark.

出版信息

Eur J Cancer. 1992;28(2-3):410-5. doi: 10.1016/s0959-8049(05)80064-4.

DOI:10.1016/s0959-8049(05)80064-4

PMID:1375486

Abstract

44 patients with metastatic testicular germ cell tumours treated with cisplatin-based chemotherapy were evaluated for prognostic implications of clinical characteristics. 22 obtained complete remission by the initial chemotherapy, and 30 are disease-free. S-LDH-1 had an overall predictive value regarding the response of 80%, S-LDH of 64%, S-AFP of 62%, and S-hCG of 62%. In multivariate analysis regarding response, only tumour volume classified according to the Royal Marsden system (P = 0.0036) and S-LDH-1 (P = 0.0069) yielded information. Regarding survival, S-LDH-1 (P = 0.0141) and an estimate of total tumour mass (P = 0.0171) had most impact with additional information from S-hCG only (P = 0.0536). We conclude that S-LDH-1 may be used as a tumour marker in addition to S-hCG and S-AFP in patients with metastatic testicular germ cell tumour.

摘要

对44例接受基于顺铂化疗的转移性睾丸生殖细胞肿瘤患者的临床特征预后影响进行了评估。22例患者通过初始化疗获得完全缓解，30例无疾病。S-LDH-1对反应的总体预测价值为80%，S-LDH为64%，S-AFP为62%，S-hCG为62%。在关于反应的多变量分析中，只有根据皇家马斯登系统分类的肿瘤体积（P = 0.0036）和S-LDH-1（P = 0.0069）提供了信息。关于生存，S-LDH-1（P = 0.0141）和总肿瘤质量估计值（P = 0.0171）影响最大，仅S-hCG提供了额外信息（P = 0.0536）。我们得出结论，在转移性睾丸生殖细胞肿瘤患者中，除了S-hCG和S-AFP外，S-LDH-1也可作为肿瘤标志物。