Dziegielewska K M, Brown W M, Gould C C, Matthews N, Sedgwick J E, Saunders N R
Clinical Neurological Sciences (Developmental) Group, Southampton General Hospital, England.
J Comp Physiol B. 1992;162(2):168-71. doi: 10.1007/BF00398343.
Fetuin is a plasma protein present in high concentrations during fetal development in animals of the order Artiodactyla. Its role is not known. The human homologue of fetuin--alpha 2HS glycoprotein--has been shown to be a negative acute phase protein in adult plasma. In the present study, the concentration of fetuin was measured in the serum of healthy cattle (Bovis bovis) and in animals with various injuries and inflammatory disorders. The levels were decreased by 30% in pregnancy but increased up to 10-fold in some trauma cases. A significant negative correlation between the concentrations of fetuin and albumin has also been found. Thus, fetuin appears to be a positive acute phase protein in cattle.
胎球蛋白是偶蹄目动物胎儿发育期间血浆中高浓度存在的一种血浆蛋白。其作用尚不清楚。胎球蛋白的人类同源物——α2HS糖蛋白——已被证明是成人血浆中的一种负急性期蛋白。在本研究中，对健康牛（黄牛）血清以及患有各种损伤和炎症性疾病的动物血清中的胎球蛋白浓度进行了测定。妊娠期间其水平下降了30%，但在一些创伤病例中升高了多达10倍。还发现胎球蛋白浓度与白蛋白浓度之间存在显著的负相关。因此，胎球蛋白在牛中似乎是一种正急性期蛋白。
