Modena M G, Mattioli A V, Parato V M, Mattioli G
Department of Cardiovascular Disease, University of Modena, Italy.
J Cardiovasc Pharmacol. 1992 Jan;19(1):148-53. doi: 10.1097/00005344-199201000-00021.
Nitrendipine is a dihydropyridine calcium antagonist that may be active when administered once daily. The aim of the study was to assess the effect of antihypertensive treatment with nitrendipine (20-40 mg) on left ventricular mass and diastolic function. Forty patients with mild to moderate hypertension (diastolic pressure greater than or equal to 90 and less than or equal to 114 mm Hg) were enrolled; a complete echo Doppler examination was performed at baseline, and 8 and 12 months after treatment in order to measure left ventricular mass and diastolic and systolic function. Only 28 patients completed the study follow-up. At month 8 nitrendipine had already successfully reduced blood pressure (mean 122 +/- 9 to 92 +/- 10 mm Hg) without modifying heart rate, and left ventricular mass index (150 +/- 48 to 123 +/- 34 g/m2), with a further reduction at month 12. Isovolumic relaxation time was reduced at month 8 from 138 +/- 28 to 111 +/- 17 ms, but the diastolic pattern was completely modified only after 1 year, with a normalization of deceleration time (from 220 +/- 35 to 188 +/- 12). Systolic function did not change. Our results indicate that nitrendipine is a powerful antihypertensive agent that reduces left ventricular mass, but requires a longer period of time to improve diastolic filling pattern.
尼群地平是一种二氢吡啶类钙拮抗剂，每日给药一次可能有效。本研究的目的是评估尼群地平（20 - 40毫克）降压治疗对左心室质量和舒张功能的影响。纳入了40例轻度至中度高血压患者（舒张压大于或等于90且小于或等于114毫米汞柱）；在基线时以及治疗后8个月和12个月进行了完整的超声多普勒检查，以测量左心室质量以及舒张和收缩功能。只有28例患者完成了研究随访。在第8个月时，尼群地平已成功降低血压（平均从122±9降至92±10毫米汞柱），且心率未改变，左心室质量指数（从150±48降至123±34克/平方米），在第12个月时进一步降低。等容舒张时间在第8个月时从138±28毫秒降至111±17毫秒，但舒张模式仅在1年后完全改变，减速时间恢复正常（从220±35降至188±12）。收缩功能未改变。我们的结果表明，尼群地平是一种强效降压药，可降低左心室质量，但需要更长时间来改善舒张充盈模式。
