KOEGLER R R, COLBERT E G, EIDUSON S
Calif Med. 1961 Jan;94(1):26-9.
Recent discoveries and refinements in technique in the field of biochemistry have led to renewed interest in the idea that a test can be developed for the diagnosis of schizophrenia. Studies directed toward that goal have included investigations of biological amines, carbohydrate metabolism, epinephrine metabolism, serotonin, taraxein and ceruloplasmin. No conclusive evidence of any biochemical abnormality in schizophrenia has been found. Although careful studies in adults have failed to confirm a theory that ceruloplasmin levels are abnormally high in schizophrenia, the surmise that it might be true in schizophrenic children was investigated, since constitutional factors seem to be very important in this condition. Thirty-four schizophrenic children and a control group of 13 "behavior problem" children were investigated. No difference was found between the two groups in serum content of copper, ceruloplasmin or ascorbic acid.
生物化学领域最近的发现和技术改进，使得人们重新对开发一种用于诊断精神分裂症的测试这一想法产生了兴趣。针对该目标的研究包括对生物胺、碳水化合物代谢、肾上腺素代谢、血清素、精神分裂素和铜蓝蛋白的研究。尚未发现精神分裂症存在任何生化异常的确凿证据。尽管对成年人的仔细研究未能证实精神分裂症患者铜蓝蛋白水平异常高这一理论，但鉴于体质因素在这种疾病中似乎非常重要，因此对精神分裂症儿童可能存在这种情况的推测进行了调查。对34名精神分裂症儿童和13名“行为问题”儿童组成的对照组进行了调查。两组在血清铜、铜蓝蛋白或抗坏血酸含量上未发现差异。
