Hornfeldt C S, Smullin D H, Schamber C D, Sun X, Larson A A
Department of Veterinary PathoBiology, University of Minnesota, St. Paul 55108.
Life Sci. 1992;50(24):1925-34. doi: 10.1016/0024-3205(92)90553-2.
Taurine (Tau), calcium (Ca+2) and opiates each produce antinociception when injected i.t. in mice. This study was initiated to determine whether there is a common mechanism underlying their antinociceptive effects. Using the abdominal stretch assay, the antinociceptive effects of both Tau (12 nmol) and Ca+2 (72 nmol) were antagonized by i.t. TAG (4.4 nmol), a Tau antagonist, but not by i.p. injection of the opiate antagonist naloxone (5 mg/kg). The antinociceptive effects of Tau and Ca+2 correlated with their ability to inhibit the intensity of caudally-directed biting and scratching behaviors produced by i.t. NMDA or kainic acid. The inhibitory effects of both Tau and Ca+2 on the biting and scratching behaviors behaviors induced by substance P or excitatory amino acids were reversed by TAG, suggesting a common mediation by Tau. These data indicate that the antinociceptive effects of both Tau and Ca+2 appear to be mediated, at least in part, by Tau but not by the release of endogenous opioid compounds. In addition, inhibition of chemical irritant-induced nociception may be produced by a simple blockade of excitatory amino acid activity.
牛磺酸（Tau）、钙（Ca+2）和阿片类物质经腹腔内注射给小鼠后均能产生抗伤害感受作用。开展本研究以确定它们的抗伤害感受作用是否存在共同机制。采用腹部伸展试验，腹腔内注射牛磺酸拮抗剂TAG（4.4 nmol）可拮抗牛磺酸（12 nmol）和Ca+2（72 nmol）的抗伤害感受作用，但腹腔注射阿片类拮抗剂纳洛酮（5 mg/kg）则无此作用。牛磺酸和Ca+2的抗伤害感受作用与其抑制腹腔内注射N-甲基-D-天冬氨酸（NMDA）或 kainic 酸所产生的尾向咬和抓挠行为强度的能力相关。TAG可逆转牛磺酸和Ca+2对P物质或兴奋性氨基酸诱导的咬和抓挠行为的抑制作用，提示牛磺酸存在共同介导作用。这些数据表明，牛磺酸和Ca+2的抗伤害感受作用似乎至少部分是由牛磺酸介导的，而非内源性阿片类化合物的释放。此外，抑制化学刺激诱导的伤害感受可能是通过简单阻断兴奋性氨基酸活性产生的。
