Silva M A, Cunha G M, Viana G S, Rao V S
Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Brasil.
Braz J Med Biol Res. 1993 Dec;26(12):1319-24.
The effect of taurine on nociception was investigated in adult male Swiss mice using the formalin and acetic acid tests. Taurine (50-200 mg/kg) injected sc into the animals (N = 6 per group) 30 min before formalin injection into the right hind paw reduced formalin-induced early phase (0-5 min) licking activity by 30-42%, but had no effect on the late phase (20-25 min) response. Writhing responses induced by acetic acid injected ip were also significantly inhibited by 49% and 56% by doses of 100 and 200 mg/kg taurine, respectively. In both tests taurine demonstrated antinociception which was significantly blocked by naloxone (1 mg/kg, sc, administered simultaneously with taurine). The naloxone-sensitive antinociceptive action of taurine was probably mediated via modulation of endogenous pain-regulatory systems that involve opioid peptides, neuropeptides like substance P and amino acids such as glutamate and aspartate.
利用福尔马林和醋酸试验，在成年雄性瑞士小鼠中研究了牛磺酸对伤害感受的影响。在向动物右后爪注射福尔马林前30分钟，皮下注射牛磺酸（50 - 200毫克/千克）（每组N = 6只），可使福尔马林诱导的早期阶段（0 - 5分钟）舔舐活动减少30% - 42%，但对晚期阶段（20 - 25分钟）的反应没有影响。腹腔注射醋酸诱导的扭体反应也分别被100毫克/千克和200毫克/千克剂量的牛磺酸显著抑制了49%和56%。在这两种试验中，牛磺酸均表现出抗伤害感受作用，该作用被纳洛酮（1毫克/千克，皮下注射，与牛磺酸同时给药）显著阻断。牛磺酸对纳洛酮敏感的抗伤害感受作用可能是通过调节内源性疼痛调节系统介导的，该系统涉及阿片肽、如P物质等神经肽以及谷氨酸和天冬氨酸等氨基酸。
