Jiang B, Zhang G Q, Ke J
Department of Pharmacology, He-nan Medical University, Zhengzhou, China.
Zhongguo Yao Li Xue Bao. 1992 Mar;13(2):171-3.
Effects of trihexyphenidyl (THP) were examined on the slow action potentials (SAP) induced by isoproterenol (Iso), histamine (His), Bay k 8644 or tetrodotoxin (TTX), in guinea pig papillary muscles. THP 10, 50, and 100 mumol.L-1 depressed the maximal upstroke velocity (Vmax) and the action potential amplitude (APA) of SAP. These effects were reversed partially by the elevation of the concentration of calcium from 2.0 to 5.6 mmol.L-1. The results suggest that THP can inhibit calcium inflow in myocardium.
研究了苯海索（THP）对豚鼠乳头肌中由异丙肾上腺素（Iso）、组胺（His）、Bay k 8644或河豚毒素（TTX）诱导的慢动作电位（SAP）的影响。10、50和100 μmol.L-1的THP降低了SAP的最大上升速度（Vmax）和动作电位幅度（APA）。将钙浓度从2.0 mmol.L-1提高到5.6 mmol.L-1可部分逆转这些作用。结果表明，THP可抑制心肌中的钙内流。
