依地酸3,6-二甲基氨基二苯并吡啶鎓对豚鼠乳头肌动作电位的影响。
Effects of 3,6-dimethylamino-dibenzopyriodonium edetate on action potentials in guinea pig papillary muscles.
作者信息
Ji G J, Zhao D H, Liu D Q, Sheng B H
机构信息
Department of Pharmacology, Fourth Military Medical University, Xi-an, China.
出版信息
Zhongguo Yao Li Xue Bao. 1993 Mar;14(2):121-4.
The effects of 3,6-dimethylamino-dibenzopyriodonium edetate (IHC-72) on action potentials (AP) and slow response action potentials of guinea pig papillary muscles were studied with intracellular microelectrodes. IHC-72 12.7, 25.4, and 50.8 mumol.L-1 decreased the maximal upstroke velocity (Vmax), amplitude of action potential (APA), over shot (OS), and resting potential (RP) while prolonged the action potential duration at 30%, 50%, 90%, and 100% repolarization (APD30, APD50, APD90, and APD100). IHC-72 25.4 and 50.8 mumol.L-1 decreased the APA, Vmax, and prolonged APD50 and APD90 under high K+ superfusion. IHC-72 25.4 and 50.8 mumol.L-1 depressed the automaticity, APA, and maximal diastolic potential (MDP) of the slow response action potentials induced by BaCl2. The results indicated that IHC-72 might nonspecifically inhibit the transmembrane movement of Ca2+, Na+, and K+.
采用细胞内微电极技术研究了依地酸3,6-二甲基氨基二苯并吡啶嗡盐（IHC-72）对豚鼠乳头肌动作电位（AP）和慢反应动作电位的影响。12.7、25.4和50.8μmol.L-1的IHC-72降低了最大除极速度（Vmax）、动作电位幅度（APA）、超射（OS）和静息电位（RP），同时延长了30%、50%、90%和100%复极化时的动作电位时程（APD30、APD50、APD90和APD100）。在高钾灌流条件下，25.4和50.8μmol.L-1的IHC-72降低了APA、Vmax，并延长了APD50和APD90。25.4和50.8μmol.L-1的IHC-72抑制了BaCl2诱导的慢反应动作电位的自律性、APA和最大舒张电位（MDP）。结果表明，IHC-72可能非特异性抑制Ca2+、Na+和K+的跨膜转运。
Zotero 插件