Pardee A B, Keyomarsi K
Dana-Farber Cancer Institute, Boston, Massachusetts.
Curr Opin Cell Biol. 1992 Apr;4(2):186-91. doi: 10.1016/0955-0674(92)90031-7.
Recent developments on mechanisms that control cell multiplication, using molecular biology, are renewing interest in inhibitors and activators. A great deal of information has been gained in the past through the use of chemicals that modify passage through the cell cycle. The kinds of inhibitors, their sites of action that disrupt functions essential for proliferation, their usefulness in synchronizing cultures and, importantly, their therapeutic value, have been the subject of many investigations.
利用分子生物学对控制细胞增殖机制的最新研究进展，重新引发了人们对抑制剂和激活剂的兴趣。过去通过使用能够改变细胞周期进程的化学物质，已经获得了大量信息。抑制剂的种类、它们破坏增殖所需功能的作用位点、它们在同步培养中的效用，以及重要的是它们的治疗价值，一直是许多研究的主题。
