A dipolar amino acid substitution induces voltage-dependent transitions between two stable conductance states in gramicidin channels.
作者信息
Oiki S, Koeppe R E, Andersen O S
机构信息
Department of Physiology and Biophysics, Cornell University Medical College, New York, New York 10021.
出版信息
Biophys J. 1992 Apr;62(1):28-30. doi: 10.1016/S0006-3495(92)81768-X.
Abstract
摘要
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A dipolar amino acid substitution induces voltage-dependent transitions between two stable conductance states in gramicidin channels.双极氨基酸取代诱导短杆菌肽通道中两个稳定电导状态之间的电压依赖性转变。
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Noncontact dipole effects on channel permeation. I. Experiments with (5F-indole)Trp13 gramicidin A channels.非接触偶极子对通道渗透的影响。I. 对（5F-吲哚）色氨酸13短杆菌肽A通道的实验。
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Formation of non-beta 6.3-helical gramicidin channels between sequence-substituted gramicidin analogues.序列取代的短杆菌肽类似物之间形成非β 6.3螺旋短杆菌肽通道。
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Formation of non-beta 6.3-helical gramicidin channels between sequence-substituted gramicidin analogues.序列取代的短杆菌肽类似物之间形成非β 6.3螺旋短杆菌肽通道。
Biophys J. 1992 Apr;62(1):145-57; discussion 157-9. doi: 10.1016/S0006-3495(92)81801-5.
本文引用的文献
1
The gramicidin A transmembrane channel: a proposed pi(L,D) helix.短杆菌肽A跨膜通道：一种推测的π（L，D）螺旋
Proc Natl Acad Sci U S A. 1971 Mar;68(3):672-6. doi: 10.1073/pnas.68.3.672.
2
Induction of conductance heterogeneity in gramicidin channels.短杆菌肽通道中电导异质性的诱导。
Biochemistry. 1989 Aug 8;28(16):6571-83. doi: 10.1021/bi00442a007.
3
Single-channel studies on linear gramicidins with altered amino acid side chains. Effects of altering the polarity of the side chain at position 1 in gramicidin A.对具有改变氨基酸侧链的线性短杆菌肽的单通道研究。改变短杆菌肽A中第1位侧链极性的影响。
Biophys J. 1986 Mar;49(3):673-86. doi: 10.1016/S0006-3495(86)83694-3.
4
Open channel noise. VI. Analysis of amplitude histograms to determine rapid kinetic parameters.开放通道噪声。VI. 用于确定快速动力学参数的幅度直方图分析
Biophys J. 1991 Sep;60(3):577-87. doi: 10.1016/S0006-3495(91)82087-2.
5
Energetics of gramicidin hybrid channel formation as a test for structural equivalence. Side-chain substitutions in the native sequence.作为结构等效性测试的短杆菌肽杂交通道形成的能量学。天然序列中的侧链取代。
J Mol Biol. 1990 Jan 5;211(1):221-34. doi: 10.1016/0022-2836(90)90022-E.
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