Ndoye A, Troutaud D, Rougier F, Deschaux P
Laboratory of Animal Physiology and Comparative Immunology, Limoges, France.
Ann N Y Acad Sci. 1992 Apr 15;650:160-4. doi: 10.1111/j.1749-6632.1992.tb49114.x.
Lymphocytes from peripheral blood of rainbow trout are put in the presence of increasing concentrations of substance P (SP) and somatostatin (SOM). We have shown that SP stimulates and SOM inhibits lymphoproliferation and that the effects are dose dependent. These results suggest that SP and SOM receptors may exist on fish peripheral blood lymphocytes. When cells are stimulated by PHA or LPS, the presence of SP enhances the response to PHA whereas it only modifies the response to LPS to a slight extent. The presence of SOM inhibits PHA- or LPS-induced stimulation. The inhibition of the proliferation is higher in the case of LPS-stimulated cells. These results suggest that there is an unequal distribution of neuropeptide receptors among the various lymphocyte subpopulations.
将虹鳟外周血中的淋巴细胞置于浓度不断增加的P物质（SP）和生长抑素（SOM）中。我们已经表明，SP刺激而SOM抑制淋巴细胞增殖，且这些作用呈剂量依赖性。这些结果表明，鱼类外周血淋巴细胞上可能存在SP和SOM受体。当细胞受到PHA或LPS刺激时，SP的存在增强了对PHA的反应，而对LPS反应的改变程度较小。SOM的存在抑制PHA或LPS诱导的刺激。在LPS刺激的细胞中，增殖抑制作用更强。这些结果表明，神经肽受体在不同淋巴细胞亚群中的分布不均。
