Bhave S A, Pandit A N, Singh S, Walia B N, Tanner M S
Department of Paediatrics, King Edward Memorial Hospital, Pune, Maharashtra, India.
Ann Trop Paediatr. 1992;12(1):23-30. doi: 10.1080/02724936.1992.11747542.
Previous studies have led to the hypothesis that the gross hepatic copper storage characteristic of Indian childhood cirrhosis (ICC) is due to the early introduction of animal milk feeds which have been contaminated with copper from brass household utensils. Amongst the families of 100 cases of ICC, the incidence of ICC in children born after dietary advice had been given (1/86) was significantly lower than in older siblings (12/125). This study attempted to document the incidence of ICC and the usage of brass before and after an intervention programme in Pune District advising against this pattern of infant feeding. The study encountered numerous difficulties in data gathering, but documented a fall in ICC prevalence resulting in its virtual disappearance in Pune District. This contrasted with an unchanged incidence in Chandigarh. Although a fall in brass usage was seen in Pune District, this was actually a spontaneous sociological change rather than a result of health education.
以往的研究提出了这样一种假说，即印度儿童肝硬化（ICC）肝脏铜大量蓄积的特征是由于过早引入了被黄铜家用器具中的铜污染的动物奶喂养。在100例ICC患儿的家庭中，在给出饮食建议后出生的儿童中ICC的发病率（1/86）显著低于其年长同胞（12/125）。本研究试图记录在普纳区开展一项反对这种婴儿喂养模式的干预项目前后ICC的发病率以及黄铜的使用情况。该研究在数据收集过程中遇到了诸多困难，但记录到ICC患病率下降，在普纳区几乎消失。这与昌迪加尔发病率未变形成对比。虽然在普纳区观察到黄铜使用量下降，但这实际上是一种自发的社会变化，而非健康教育的结果。
