一种35千道尔顿的Fos相关抗原与P物质和强啡肽在纹状体神经元中共定位。

A 35 kDa Fos-related antigen is co-localized with substance P and dynorphin in striatal neurons.

作者信息

Zhang W Q, Pennypacker K R, Ye H, Merchenthaler I J, Grimes L, Iadarola M J, Hong J S

机构信息

Laboratory of Molecular and Integrative Neuroscience, National Institute of Environmental Health Sciences, National Institute of Health Research Triangle Park, NC 27709.

出版信息

Brain Res. 1992 Apr 17;577(2):312-7. doi: 10.1016/0006-8993(92)90289-l.

DOI:10.1016/0006-8993(92)90289-l

PMID:1376635

Abstract

The rat striatum after dopamine denervation followed by repeated apomorphine treatment was examined for the co-expression of c-fos and Fos-related antigens with dynorphin, substance P and [Met5]enkephalin using Western blot and immunohistochemical techniques. Administration of apomorphine, a dopamine agonist, elevated the level of 35 kDa Fos-related antigen which co-localized with dynorphin and substance P, but not enkephalin, in striatal neurons.

摘要

采用蛋白质免疫印迹法和免疫组织化学技术，对多巴胺去神经支配后反复给予阿扑吗啡处理的大鼠纹状体进行检测，以观察c-fos和Fos相关抗原与强啡肽、P物质和[Met5]脑啡肽的共表达情况。多巴胺激动剂阿扑吗啡的给药，提高了35 kDa Fos相关抗原的水平，该抗原在纹状体神经元中与强啡肽和P物质共定位，但不与脑啡肽共定位。