肝细胞癌患者的血清α1-抗胰蛋白酶

Serum alpha 1-antitrypsin in patients with hepatocellular carcinoma.

作者信息

Lee H B, Yoo O J, Ham J S, Lee M H

机构信息

Department of Biological Science and Engineering, Korea Advanced Institute of Science and Technology, Taejon.

出版信息

Clin Chim Acta. 1992 Mar 31;206(3):225-30. doi: 10.1016/0009-8981(92)90092-5.

DOI:10.1016/0009-8981(92)90092-5

PMID:1376649

Abstract

To evaluate the diagnostic value of alpha 1-antitrypsin (alpha-AT) as a tumor marker for hepatocellular carcinoma (HCC), we studied the serum levels of alpha-AT by rocket immunoelectrophoresis and alpha-fetoprotein (alpha-FP) by radioimmunoassay in 46 proven HCC patients, 43 cirrhosis patients and 200 healthy blood donors. The mean alpha-AT level of the 46 patients with HCC (4.8 +/- 2.7 mg/ml) was significantly higher than that of 200 healthy control subjects (1.7 +/- 0.7 mg/ml) (P less than 0.0001). The sensitivity of alpha-AT in 24 patients with high level of alpha-FP (greater than 400 ng/ml) and 22 patients with low level of alpha-FP (less than 400 ng/ml) were 96% and 64%, respectively. There was no substantial correlation between alpha-FP and alpha-AT in the two groups (alpha-FP greater than 400 ng/ml, alpha-FP less than 400 ng/ml) (r = 0.078, 0.064). The sensitivity for HCC using alpha-FP level alone (greater than 400 ng/ml) was only 52%, and the sensitivity using alpha-AT level alone (greater than 3.2 mg/ml) was 76% of the 46 patients. Combining both tests, sensitivity was improved only to 80%.

摘要

为评估α1-抗胰蛋白酶（α-AT）作为肝细胞癌（HCC）肿瘤标志物的诊断价值，我们采用火箭免疫电泳法研究了46例确诊的HCC患者、43例肝硬化患者及200名健康献血者的血清α-AT水平，并采用放射免疫分析法研究了甲胎蛋白（α-FP）水平。46例HCC患者的α-AT平均水平（4.8±2.7mg/ml）显著高于200名健康对照者（1.7±0.7mg/ml）（P＜0.0001）。α-FP水平高（＞400ng/ml）的24例患者及α-FP水平低（＜400ng/ml）的22例患者中，α-AT的敏感性分别为96%和64%。两组（α-FP＞400ng/ml、α-FP＜400ng/ml）中α-FP与α-AT之间无显著相关性（r = 0.078，0.064）。仅使用α-FP水平（＞400ng/ml）对HCC的敏感性仅为52%，仅使用α-AT水平（＞3.2mg/ml）对46例患者的敏感性为76%。联合两项检测，敏感性仅提高至80%。