Evans P J, Evans R, Kovar I Z, Holton A F, Halliwell B
Department of Biochemistry, Kings College, London, UK.
FEBS Lett. 1992 Jun 1;303(2-3):210-2. doi: 10.1016/0014-5793(92)80521-h.
The bleomycin assay measures non-transferrin-bound iron, able to catalyze free radical reactions, in human plasma. No bleomycin-detectable iron is present in plasma from healthy adults. However, plasma from 3/15 premature babies was positive in this assay. Plasma from 52 apparently-healthy term babies was analyzed and 11 were positive in the bleomycin assay. Hence not only some premature but also some full-term apparently-healthy babies may be at risk of severe oxidative damage.
博来霉素检测法可测定人血浆中能催化自由基反应的非转铁蛋白结合铁。健康成年人的血浆中不存在可被博来霉素检测到的铁。然而，15例早产儿中有3例的血浆在该检测中呈阳性。对52例看似健康的足月儿的血浆进行了分析，其中11例在博来霉素检测中呈阳性。因此，不仅一些早产儿，而且一些看似健康的足月儿也可能面临严重氧化损伤的风险。
