Abdulla F, Dawe G, Scorsa A M, Rispoli V, Stephenson J D
Department of Psychology, University of London, UK.
Funct Neurol. 1992 Mar-Apr;7(2):141-4.
The effects of tetrahydro-9-aminoacridine (THA) were studied on the electrocortical activity of control rats and of rats with a unilateral lesion of the nucleus basalis magnocellularis (NBM) produced by alpha-amino-3-hydroxy-4-isoxozole propionic acid (AMPA). This lesion almost completely deprived the lesioned hemisphere of its cholinergic innervation. In control rats, THA (10 mg/kg i.p.) increased the amplitude of the slow components of the electrocorticogram (less than 9 Hz). These effects were antagonised by atropine (5 mg/kg i.p.). Lesion of the NBM alone decreased the amplitude of frequencies in the 12-16 Hz frequency band but did not significantly affect the slower frequencies. THA (10 mg/kg) restored the amplitude of the 12-16 Hz activity to the level seen in control rats before THA but did not affect activity in the other frequency bands. The results suggest that THA requires some residual cholinergic innervation in order to exert its effect.
研究了四氢-9-氨基吖啶（THA）对正常大鼠以及由α-氨基-3-羟基-4-异恶唑丙酸（AMPA）造成单侧大细胞基底核（NBM）损伤的大鼠的皮层电活动的影响。这种损伤几乎完全剥夺了损伤半球的胆碱能神经支配。在正常大鼠中，腹腔注射THA（10mg/kg）可增加皮层电图慢成分（小于9Hz）的波幅。这些效应可被腹腔注射阿托品（5mg/kg）拮抗。单独的NBM损伤降低了12-16Hz频段的频率波幅，但对较慢频率没有显著影响。THA（10mg/kg）将12-16Hz活动的波幅恢复到THA给药前正常大鼠的水平，但不影响其他频段的活动。结果表明，THA需要一些残余的胆碱能神经支配才能发挥其作用。
