Ferdinandy P, Koltai M, Tosaki A, Berthet P, Tarrade T, Esanu A, Braquet P
Institut Henri Beaufour, Le Plessis Robinson, France.
J Cardiovasc Pharmacol. 1992 Feb;19(2):181-9. doi: 10.1097/00005344-199202000-00005.
The effect of cicletanine, a novel furopyridine antihypertensive drug was compared with that of nitrendipine, a dihydropyridine slow calcium channel blocker, on cardiac function and reperfusion-induced ventricular arrhythmias in isolated working rat hearts subjected to 10-min ischemia induced by ligation of the left main coronary artery followed by 10-min reperfusion. Before ischemia, cicletanine and nitrendipine, perfused at concentrations of 3 x 10(-5), 6 x 10(-5), 10(-4), and 2 x 10(-4) or 10(-8) M, respectively, did not influence heart rate (HR), LV developed pressure (LVDP), its first derivative (LVdP/dtmax), and LV end-diastolic pressure (LVEDP), whereas aortic flow (AF) was decreased by 2 x 10(-4) M cicletanine only. Coronary flow (CF) remained unchanged by various cicletanine concentrations but was slightly increased by nitrendipine. In the concentration range of 3 x 10(-5)-10(-4) M, cicletanine improved AF either in ischemia or during reperfusion, whereas 2 x 10(-4) M had no such effect. Nitrendipine slightly attenuated ischemia/reperfusion-induced decrease in AF. Cicletanine and nitrendipine enhanced LVDP during ischemia. Ischemia-induced deterioration of LVdP/dtmax was reduced by cicletanine, during reperfusion, but this parameter was reduced by nitrendipine and the highest cicletanine concentration. Cicletanine decreased LVEDP significantly during ischemia and reperfusion, but nitrendipine had no such effect. All cicletanine concentrations reduced the incidence of irreversible ventricular fibrillation (VF) during reperfusion, an effect roughly concentration dependent in the range of 3 x 10(-5)-10(-4) M, whereas nitrendipine had no influence on arrhythmias.
将新型呋喃吡啶类抗高血压药物西氯他宁与二氢吡啶类慢钙通道阻滞剂尼群地平对离体工作大鼠心脏心功能及再灌注诱导的室性心律失常的影响进行了比较。这些大鼠心脏通过结扎左冠状动脉主干诱导10分钟缺血，随后再灌注10分钟。缺血前，分别以3×10⁻⁵、6×10⁻⁵、10⁻⁴和2×10⁻⁴或10⁻⁸M的浓度灌注西氯他宁和尼群地平，均不影响心率（HR）、左心室舒张末压（LVDP）、其一阶导数（LVdP/dtmax）和左心室舒张末压（LVEDP），而仅2×10⁻⁴M西氯他宁使主动脉血流量（AF）降低。不同浓度的西氯他宁对冠状动脉血流量（CF）无影响，但尼群地平使其略有增加。在3×10⁻⁵ - 10⁻⁴M浓度范围内，西氯他宁可改善缺血或再灌注期间的AF，而2×10⁻⁴M则无此作用。尼群地平可轻微减轻缺血/再灌注诱导的AF降低。西氯他宁和尼群地平可增强缺血期间的LVDP。西氯他宁可减轻再灌注期间缺血诱导的LVdP/dtmax恶化，但尼群地平和最高浓度的西氯他宁可降低该参数。西氯他宁在缺血和再灌注期间可显著降低LVEDP，但尼群地平无此作用。所有浓度的西氯他宁均可降低再灌注期间不可逆室颤（VF）的发生率，在3×10⁻⁵ - 10⁻⁴M范围内，该作用大致呈浓度依赖性，而尼群地平对心律失常无影响。
