Tosaki A, Koltai M, Willoughby D A, Braquet P
Institut Henri Beaufour, Le Plessis Robinson, France.
J Cardiovasc Pharmacol. 1990 Feb;15(2):218-26. doi: 10.1097/00005344-199002000-00007.
Isolated hearts from normotensive (NT) and spontaneously hypertensive (SH) rats, subjected to normothermic global ischemia, were used to study whether cicletanine (a new antihypertensive drug) treatment exerts an antiarrhythmic effect against reperfusion-induced arrhythmias. The effect of the drug on myocardial ion contents (Na+, K+, Ca2+, and Mg2+) during ischemia and reperfusion was also determined. Using the optimal doses of cicletanine (30 and 100 mg/kg orally for 14 days), the incidence of reperfusion-induced ventricular fibrillation (VF) and ventricular tachycardia (VT) was reduced from their control values of 91 and 100% (after 30 min of ischemia) to 41 (p less than 0.05), 50 (p less than 0.05) and 41 (p less than 0.05), 58% in the NT group, while the corresponding value in the SH group for VF and VT were 17 (p less than 0.001), 33 (p less than 0.01) and 17 (p less than 0.001), 25% (p less than 0.001), respectively. The results obtained indicate that the cardioprotective effect of cicletanine was greater in the SH group than in the NT group. Cicletanine significantly reduced the ischemia- and reperfusion-induced myocardial Na+ and Ca2+ gains and inhibited the loss of myocardial K+ and Mg2+ in both NT and SH groups. The antiarrhythmic effect of cicletanine appears to be correlated with the preservation of myocardial Na+, K+, Ca2+, and Mg2+ contents via an ion transport modulation.
使用来自正常血压（NT）大鼠和自发性高血压（SH）大鼠的离体心脏，使其经历常温全心缺血，以研究西氯他宁（一种新型抗高血压药物）治疗是否对再灌注诱导的心律失常发挥抗心律失常作用。还测定了该药物在缺血和再灌注期间对心肌离子含量（Na +、K +、Ca2 +和Mg2 +）的影响。使用西氯他宁的最佳剂量（口服30和100 mg/kg，持续14天），再灌注诱导的室颤（VF）和室性心动过速（VT）的发生率从其对照组值（缺血30分钟后）的91%和100%分别降至NT组的41%（p < 0.05）、50%（p < 0.05）以及41%（p < 0.05）、58%，而SH组中VF和VT的相应值分别为17%（p < 0.001）、33%（p < 0.01）以及17%（p < 0.001）、25%（p < 0.001）。所得结果表明，西氯他宁在SH组中的心脏保护作用大于NT组。西氯他宁显著降低了缺血和再灌注诱导的心肌Na +和Ca2 +增加，并抑制了NT组和SH组中心肌K +和Mg2 +的丢失。西氯他宁的抗心律失常作用似乎与通过离子转运调节来维持心肌Na +、K +、Ca2 +和Mg2 +含量相关。
