Viskoper J R, Laszt A, Faraggi D, Yaskil E
Center for the Prevention of Cardiovascular Diseases, Barzilai Medical Center, Ashkelon, Israel.
J Cardiovasc Pharmacol. 1992;19 Suppl 3:S74-5.
The blood pressure-lowering effect of isradipine at 1.25-2.5 mg twice daily (taken at 0700 and 1900 h) was assessed in a double-blind study involving 28 men with mild-to-moderate hypertension. After a 4-week placebo period, patients were randomized to receive either isradipine (group I) or placebo (group II) for 8 weeks. At the end of the placebo and active-treatment periods, patients were evaluated by 24-h ambulatory blood pressure monitoring. Data were analyzed according to two time periods: daytime, 1000-2300 h; nighttime and early morning, 2300-1000 h. Intersubject analyses were performed comparing values at the end of placebo with those at the end of active treatment. Intrasubject two-way analysis of variance showed that the time of day or night had no influence on blood pressure changes. Comparison of systolic (SBP) and diastolic (DBP) blood pressures with isradipine indicated that there were significantly greater average decreases in SBP at 0600-0800 h than at 1800-2000 h (p = 0.038), and at 0800-1100 h than at 2000-2300 h (p = 0.045). This was also true for the average decreases in DBP (p = 0.006). In conclusion, isradipine exerts blood pressure control throughout 24 h with a pronounced action during the early morning (0600-0800 h) period.
在一项双盲研究中，对28名轻度至中度高血压男性患者评估了每日两次服用1.25 - 2.5毫克伊拉地平（于07:00和19:00服用）的降压效果。在为期4周的安慰剂期后，患者被随机分为两组，分别接受伊拉地平治疗（第一组）或安慰剂治疗（第二组），为期8周。在安慰剂期和积极治疗期结束时，通过24小时动态血压监测对患者进行评估。数据根据两个时间段进行分析：白天，10:00 - 23:00；夜间和清晨，23:00 - 10:00。进行受试者间分析，比较安慰剂期结束时与积极治疗期结束时的值。受试者内双向方差分析表明，白天或夜晚时间对血压变化没有影响。将收缩压（SBP）和舒张压（DBP）与伊拉地平进行比较表明，在06:00 - 08:00时SBP的平均下降幅度显著大于18:00 - 20:00时（p = 0.038），在08:00 - 11:00时大于20:00 - 23:00时（p = 0.045）。DBP的平均下降幅度情况也是如此（p = 0.006）。总之，伊拉地平在24小时内均能控制血压，在清晨（06:00 - 08:00）期间作用尤为显著。
