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脊髓灰质炎病毒耐药性突变体的快速发展。

Rapid development of drug-resistant mutants of poliovirus.

作者信息

MELNICK J L, CROWTHER D, BARRERA-ORO J

出版信息

Science. 1961 Aug 25;134(3478):557. doi: 10.1126/science.134.3478.557.

DOI:10.1126/science.134.3478.557
PMID:13769274
Abstract

Guanidine hydrochloride is a potent inhibitor of poliovirus synthesis in cell culture. However, the viral progeny which do grow in the presence of guani-dine may become approximately 10,000 times more resistant to the drug. The phenomenon of drug resistance poses yet another problem in the search for a satisfactory viral chemotherapeutic agent.

摘要

盐酸胍是细胞培养中脊髓灰质炎病毒合成的有效抑制剂。然而，在胍存在的情况下仍能生长的病毒后代对该药物的抗性可能会增加约10000倍。耐药现象在寻找令人满意的病毒化疗药物方面又带来了另一个问题。

相似文献

1
Rapid development of drug-resistant mutants of poliovirus.脊髓灰质炎病毒耐药性突变体的快速发展。
Science. 1961 Aug 25;134(3478):557. doi: 10.1126/science.134.3478.557.
2
Studies of the inhibitory action of guanidine on poliovirus multiplication in cell cultures.胍对细胞培养中脊髓灰质炎病毒增殖的抑制作用研究。
Virology. 1961 Sep;15:65-74. doi: 10.1016/0042-6822(61)90078-2.
3
[On the inhibitory activity, in vitro, of guanidine against the poliomyelitis virus. IV. Influence of guanidine on viral multiplication].[胍对脊髓灰质炎病毒的体外抑制活性。IV. 胍对病毒增殖的影响]
Boll Soc Ital Biol Sper. 1961 Jun 15;37:540-1.
4
[On the inhibitory activity, in vitro, of guanidine against the poliomyelitis virus. V. Curative activity of guanidine in infections of cell cultures by poliomyelitis virus I].[胍对脊髓灰质炎病毒的体外抑制活性。V. 胍对脊髓灰质炎病毒I感染细胞培养物的治疗活性]
Boll Soc Ital Biol Sper. 1961 Jun 15;37:542-4.
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[Inhibition of the in vitro multiplication of poliomyelitis viruses using guanidine].[使用胍抑制脊髓灰质炎病毒的体外增殖]
Boll Soc Ital Biol Sper. 1961 May 15;37:395-7.
6
[Inhibition of the multiplication in vitro of poliomyelitis viruses by guanidine. VIII. Elective inhibitory activity of guanidine on the PCE of enteroviruses].[胍对脊髓灰质炎病毒体外增殖的抑制作用。VIII. 胍对肠道病毒PCE的选择性抑制活性]
Boll Soc Ital Biol Sper. 1962 Jan 15;38:8-10.
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Antiviral effect of guanidine and its derivatives. I. The inhibitory effect of guanidine on the multiplication of poliomyelitis virus in tissue culture.胍及其衍生物的抗病毒作用。I. 胍对脊髓灰质炎病毒在组织培养中增殖的抑制作用。
Keio J Med. 1961 Dec;10:257-65. doi: 10.2302/kjm.10.257.
8
[Inhibitory action of guanidine on the multiplication of enteroviruses and especially of polioviruses].[胍对肠道病毒尤其是脊髓灰质炎病毒增殖的抑制作用]
Boll Ist Sieroter Milan. 1962 Mar-Apr;41:111-20.
9
[Inhibition of the multiplication in vitro of poliomyelitis viruses by guanidine. VII. Absence of interference of vitamins, purine and pyrimidine bases in the inhibition by guanidine].[胍对脊髓灰质炎病毒体外增殖的抑制作用。VII. 维生素、嘌呤及嘧啶碱基在胍抑制作用中不存在干扰]
Boll Soc Ital Biol Sper. 1962 Jan 15;38:7-8.
10
In vitro inhibition of infectivity of polio viruses by guanidine.胍对脊髓灰质炎病毒传染性的体外抑制作用。
Nature. 1962 Jan 6;193:97-8. doi: 10.1038/193097a0.

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Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance.伴侣蛋白介导的折叠过程中的进化限制提供了一种不易产生耐药性的抗病毒方法。
Genes Dev. 2007 Jan 15;21(2):195-205. doi: 10.1101/gad.1505307.
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RESCUE OF DRUG-REQUIRING AND DRUG-INHIBITED ENTEROVIRUSES.对依赖药物和受药物抑制的肠道病毒的挽救
Proc Natl Acad Sci U S A. 1964 Dec;52(6):1419-26. doi: 10.1073/pnas.52.6.1419.
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CHARACTERS OF GUANIDINE RESISTANT MUTANTS OF TYPE 1 POLIOVIRUS.1型脊髓灰质炎病毒胍抗性突变体的特征
Arch Gesamte Virusforsch. 1964;14:238-52. doi: 10.1007/BF01555095.
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Proc Natl Acad Sci U S A. 1963 Jun;49(6):843-9. doi: 10.1073/pnas.49.6.843.
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Mutations in the 2C region of poliovirus responsible for altered sensitivity to benzimidazole derivatives.脊髓灰质炎病毒2C区域的突变与对苯并咪唑衍生物敏感性改变有关。
J Virol. 2000 May;74(9):4146-54. doi: 10.1128/jvi.74.9.4146-4154.2000.
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